The competition between drugs: which is worse - cortisone or MTX?

The competition between drugs: which is worse - cortisone or MTX?

The competition between medications: What is worse – cortisone or MTX?

When treating inflammatory diseases such as rheumatism and autoimmune diseases, doctors are often faced with the decision of which medication to prescribe to their patients. Two commonly used medications in this area are cortisone and methotrexate (MTX). Both have their specific advantages and disadvantages, and it is important to understand the differences between them in order to choose the best treatment option.

In this article we will look at the properties, effects and side effects of cortisone and MTX to determine which of the two drugs can be considered “worse”.

Cortisone

What is cortisone?

Cortisone, also known as glucocorticoid, is a hormone naturally produced by the body. It has anti-inflammatory effects and is often used to treat inflammatory diseases. Cortisone can be administered in the form of tablets, injections or creams and has various areas of application.

How does cortisone work?

Cortisone works by inhibiting the production of inflammatory mediators and suppressing the immune system. This leads to a reduction in inflammation and symptoms such as swelling, pain and redness. Cortisone can also impair immune system function, which can lead to a reduced immune response.

Side effects of cortisone

Although cortisone is effective in treating inflammation, it can also be associated with side effects. The most common side effects include weight gain, increased blood sugar, osteoporosis, skin changes and mood changes. Long-term use of cortisone can lead to more serious side effects such as bone fractures, muscle loss, susceptibility to infection and hormonal changes.

When is cortisone used?

Cortisone is used in a variety of situations, including the treatment of autoimmune diseases such as rheumatoid arthritis, lupus and asthma. It can also be used for acute inflammation, allergies and skin diseases. The dosage and duration of treatment with cortisone depends on the specific disease and the individual patient.

Methotrexate (MTX)

What is methotrexate?

Methotrexate (MTX) is a drug that was initially developed as a chemotherapy for cancer. However, it has also been shown to be effective in treating inflammatory diseases, particularly rheumatoid arthritis. MTX is usually taken as a tablet but can also be given as an injection.

How does methotrexate work?

MTX works by suppressing the immune system and reducing the activity of cells involved in inflammatory processes. It also inhibits the production of DNA and RNA, which means that the affected cells can no longer divide as quickly. This helps reduce inflammation and slow disease progression.

Side effects of methotrexate

As with most medications, MTX also has certain side effects. The most common include nausea, fatigue, hair loss, increased risk of infection and liver dysfunction. It is important to have regular blood tests to monitor liver values. In rare cases, MTX can also cause serious side effects such as pneumonia and bone marrow damage.

When is methotrexate used?

MTX is primarily used in the treatment of rheumatoid arthritis, but may also be prescribed for other autoimmune diseases such as psoriatic arthritis and systemic lupus erythematosus. It is often used in combination with other anti-inflammatory medications to relieve symptoms and reduce disease activity.

Cortisone vs. Methotrexate: Which is Worse?

It is difficult to say which of the two drugs can be considered “worse” as both have their specific advantages and disadvantages. The choice between cortisone and MTX depends on several factors, including the disease, individual disease activity, symptom severity, and patient tolerance.

Cortisone can be effective quickly in acute episodes of inflammation, but long-term use can lead to serious side effects. MTX, on the other hand, has a slower effect but fewer side effects compared to cortisone.

In some cases, doctors may recommend a combination therapy of cortisone and MTX to reap the benefits of both medications and minimize side effects. It is important to carry out the treatment under medical supervision and to carry out regular check-ups to check the tolerance and effectiveness of the medication.

Frequently asked questions

1. Which drug is stronger, cortisone or MTX?

Cortisone and MTX are not active ingredients that can be directly compared with each other because they have different mechanisms of action. However, both drugs can be effective, depending on the type of inflammatory disease and the patient's individual circumstances.

2. What side effects are common with cortisone and MTX?

Common side effects of cortisone include weight gain, increased blood sugar, osteoporosis, and mood swings. With MTX, nausea, fatigue, hair loss, increased risk of infection and liver dysfunction are common side effects.

3. How long does it take for cortisone and MTX to work?

Cortisone can work quickly and relieve symptoms such as pain and swelling within a few hours or days. MTX, on the other hand, has a slower acting effect and may take several weeks to months to notice improvement in symptoms.

4. Can I just stop taking cortisone or MTX?

No, it is important not to suddenly stop taking cortisone or MTX as this may cause a relapse of symptoms. Treatment with these medications should be under medical supervision, and changes in dosage or discontinuation should be made in consultation with the doctor.

5. Can I take cortisone and MTX at the same time?

Yes, in some cases a combination therapy of cortisone and MTX may be recommended to reap the benefits of both medications. However, this should always be done under medical supervision as close monitoring of side effects is required.

Conclusion

Cortisone and methotrexate (MTX) are both important medications in the treatment of inflammatory diseases. Both have their advantages and disadvantages, and the choice between the two depends on the patient's specific condition and individual circumstances. It is important to carry out the treatment under medical supervision and to carry out regular check-ups to check the tolerance and effectiveness of the medication.